Simutrans 120.1.3

Simutrans is a strategy game in which you manage and optimize various forms of transportation. Transport passengers and goods by rail, road, ship or air. Simutrans is a very complete and polished game; there is even a whole set of various graphic themes to download and use. Personally I really liked the Comic-set which can be seen in the screenshot below. Oh, and did I mention you can play multiplayer with friends?

Beautiful pixel graphics which great attention to detail.